Galenia africana extract as an alternative to typical azoles against Candida species
| dc.contributor.author | Mouton, Charnice Rene’ | |
| dc.date.accessioned | 2025-11-21T09:09:12Z | |
| dc.date.available | 2025-11-21T09:09:12Z | |
| dc.date.issued | 2025 | |
| dc.description.abstract | Candidiasis is a common infection caused by Candida species, often associated with immune compromised patients. Due to the prevalence of candidal resistance to typical azole treatments, alternative forms of therapies should be investigated. The use of medicinal plants as an alternative form of therapy has become a topic of interest in the scientific community. Galenia africana has shown a lot of potential as an antimicrobial plant extract. In this study, the antifungal activity of the ethanolic and ethyl acetate extraction of Galenia africana was investigated against fluconazole-resistant and susceptible Candida species. High-performance liquid chromatography and nuclear magnetic resonance were employed to separate, isolate and purify the active compounds of Galenia africana followed by evaluating the antifungal activity using broth microdilution, synergistic and time kill assays. Three compounds were isolated from Galenia africana, identified as (S)-5,7-dihydroxy flavone (1), (E)-2',4'-dihydroxychalcone (2), and (S)-2',5,7,-trihydroxyflavanone (3). The results showed significant antifungal activity below 500μg/ml which confirms that Galenia africana can be used as a potential antifungal against fluconazole resistant strains of Candida. | |
| dc.identifier.citation | N/A | |
| dc.identifier.uri | https://hdl.handle.net/10566/21450 | |
| dc.language.iso | en | |
| dc.publisher | University of the Western Cape | |
| dc.subject | Antimicrobial | |
| dc.subject | Azoles | |
| dc.subject | Candidiasis | |
| dc.subject | Chromatography | |
| dc.subject | Galenia africana | |
| dc.title | Galenia africana extract as an alternative to typical azoles against Candida species | |
| dc.type | Thesis |