Stress modulation as a means to improve yeasts for lignocellulose bioconversion

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dc.contributor.authorBrandt, Bianca
dc.contributor.authorJansen, Trudy
dc.contributor.authorDen Haan, Riaan
dc.date.accessioned2021-11-17T11:29:00Z
dc.date.available2021-11-17T11:29:00Z
dc.date.issued2021
dc.description.abstractThe second-generation (2G) fermentation environment for lignocellulose conversion presents unique challenges to the fermentative organism that do not necessarily exist in other industrial fermentations. While extreme osmotic, heat, and nutrient starvation stresses are observed in sugar- and starch-based fermentation environments, additional pre-treatment-derived inhibitor stress, potentially exacerbated by stresses such as pH and product tolerance, exist in the 2G environment. Furthermore, in a consolidated bioprocessing (CBP) context, the organism is also challenged to secrete enzymes that may themselves lead to unfolded protein response and other stresses. This review will discuss responses of the yeast Saccharomyces cerevisiae to 2G-specific stresses and stress modulation strategies that can be followed to improve yeasts for this application. We also explore published –omics data and discuss relevant rational engineering, reverse engineering, and adaptation strategies, with the view of identifying genes or alleles that will make positive contributions to the overall robustness of 2G industrial strains.en_US
dc.identifier.citationBrandt, B. et al. (2021). Stress modulation as a means to improve yeasts for lignocellulose bioconversion. Applied Microbiology and Biotechnology, 105. 4899-4918. https://doi.org/10.1007/s00253-021-11383-yen_US
dc.identifier.issn1432-0614
dc.identifier.urihttps://doi.org/10.1007/s00253-021-11383-y
dc.identifier.urihttp://hdl.handle.net/10566/7030
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.subjectStressen_US
dc.subjectYeastsen_US
dc.subjectSecond-generation biofuelen_US
dc.subjectNutrient starvationen_US
dc.titleStress modulation as a means to improve yeasts for lignocellulose bioconversionen_US
dc.typeArticleen_US

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