The antioxidant and in vitro wound healing activity of cotyledon orbiculata aqueous extract and the synthesized biogenic silver nanoparticles

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dc.contributor.authorTyavambiza, Caroline
dc.contributor.authorMeyer, Mervin
dc.contributor.authorMadiehe, Abram Madimabe
dc.date.accessioned2023-03-28T07:12:45Z
dc.date.available2023-03-28T07:12:45Z
dc.date.issued2022
dc.description.abstractThe synthesis of silver nanoparticles using biogenic methods, particularly plants, has led to the discovery of several effective nanoparticles. In many instances, plant-derived silver nanoparticles have been shown to have more activity than the plant extract which was used to synthesize the nanoparticles. Silver nanoparticles have been successfully synthesized using the medicinal plant, Cotyledon orbiculata. This is a shrub found in the Western Cape province of South Africa. It has a long history of use in traditional medicine in the treatment of wounds and skin infections. The C. orbiculata synthesized silver nanoparticles (Cotyledon-AgNPs) were reported to have good antimicrobial and anti-inflammatory activities; however, their wound-healing properties have not been determined. This study aimed to determine the wound healing activity of Cotyledon-AgNPs using the scratch assay. Gene expression studies were also done to determine the nanoparticles’ mechanism of action. The Cotyledon-AgNPs showed good antioxidant, growth-promoting and cell migration properties.en_US
dc.identifier.citationTyavambiza, C. et al. (2022). The antioxidant and in vitro wound healing activity of cotyledon orbiculata aqueous extract and the synthesized biogenic silver nanoparticles. International Journal of Molecular Sciences, 23(24), 16094. https://doi.org/10.3390/ijms232416094en_US
dc.identifier.issn1422-0067
dc.identifier.urihttps://doi.org/10.3390/ijms232416094
dc.identifier.urihttp://hdl.handle.net/10566/8671
dc.language.isoenen_US
dc.publisherMDPIen_US
dc.subjectSilver nanoparticlesen_US
dc.subjectBiotechnologyen_US
dc.subjectCell migrationen_US
dc.subjectCotyledon orbiculataen_US
dc.subjectSouth Africaen_US
dc.titleThe antioxidant and in vitro wound healing activity of cotyledon orbiculata aqueous extract and the synthesized biogenic silver nanoparticlesen_US
dc.typeArticleen_US

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