The antioxidant and in vitro wound healing activity of cotyledon orbiculata aqueous extract and the synthesized biogenic silver nanoparticles
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Date
2022
Journal Title
Journal ISSN
Volume Title
Publisher
MDPI
Abstract
The synthesis of silver nanoparticles using biogenic methods, particularly plants, has led to
the discovery of several effective nanoparticles. In many instances, plant-derived silver nanoparticles
have been shown to have more activity than the plant extract which was used to synthesize the
nanoparticles. Silver nanoparticles have been successfully synthesized using the medicinal plant,
Cotyledon orbiculata. This is a shrub found in the Western Cape province of South Africa. It has a long
history of use in traditional medicine in the treatment of wounds and skin infections. The C. orbiculata
synthesized silver nanoparticles (Cotyledon-AgNPs) were reported to have good antimicrobial and
anti-inflammatory activities; however, their wound-healing properties have not been determined.
This study aimed to determine the wound healing activity of Cotyledon-AgNPs using the scratch
assay. Gene expression studies were also done to determine the nanoparticles’ mechanism of action.
The Cotyledon-AgNPs showed good antioxidant, growth-promoting and cell migration properties.
Description
Keywords
Silver nanoparticles, Biotechnology, Cell migration, Cotyledon orbiculata, South Africa
Citation
Tyavambiza, C. et al. (2022). The antioxidant and in vitro wound healing activity of cotyledon orbiculata aqueous extract and the synthesized biogenic silver nanoparticles. International Journal of Molecular Sciences, 23(24), 16094. https://doi.org/10.3390/ijms232416094