Sub-analysis of cyp-guides data: Assessing the prevalence and impact of drug-gene interactions in an ethnically diverse cohort of depressed individuals

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dc.contributor.authorCrutchley, Rustin D.
dc.contributor.authorKeuler, Nicole
dc.date.accessioned2023-06-05T09:04:02Z
dc.date.available2023-06-05T09:04:02Z
dc.date.issued2022
dc.description.abstractMinority groups are underrepresented in pharmacogenomics (PGx) research. Recent sub-analysis of CYP-GUIDES showed reduced length of stay (LOS) in depressed patients with CYP2D6 sub-functional status. Our primary objective was to determine whether PGx guided (G) versus standard treatment (S) influenced LOS among different race/ethnic groups. Secondary objectives included prevalence of drug-gene interactions (DGIs) and readmission rates (RAR). Retrospective sub-analysis of CYP-GUIDES data comprising CYP2D6 phenotypes was reclassified using standardized CYP2D6 genotype to phenotype recommendations from the Clinical Pharmacogenetics Implementation Consortium (CPIC) and Dutch Pharmacogenetics Working Group (DPWG).en_US
dc.identifier.citationCrutchley, R. D., & Keuler, N. (2022). Sub-analysis of cyp-guides data: Assessing the prevalence and impact of drug-gene interactions in an ethnically diverse cohort of depressed individuals. Frontiers in Pharmacology, 13, 884213. 10.3389/fphar.2022.884213en_US
dc.identifier.issn1663-9812
dc.identifier.urihttps://doi.org/10.3389/fphar.2022.884213
dc.identifier.urihttp://hdl.handle.net/10566/9007
dc.language.isoenen_US
dc.publisherFrontiers Mediaen_US
dc.subjectPharmaceuticen_US
dc.subjectPharmacologyen_US
dc.subjectEthnicityen_US
dc.subjectRaceen_US
dc.subjectDepressionen_US
dc.titleSub-analysis of cyp-guides data: Assessing the prevalence and impact of drug-gene interactions in an ethnically diverse cohort of depressed individualsen_US
dc.typeArticleen_US

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