Sub-analysis of cyp-guides data: Assessing the prevalence and impact of drug-gene interactions in an ethnically diverse cohort of depressed individuals
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Date
2022
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Frontiers Media
Abstract
Minority groups are underrepresented in pharmacogenomics (PGx)
research. Recent sub-analysis of CYP-GUIDES showed reduced length of stay (LOS)
in depressed patients with CYP2D6 sub-functional status. Our primary objective was to
determine whether PGx guided (G) versus standard treatment (S) influenced LOS among
different race/ethnic groups. Secondary objectives included prevalence of drug-gene
interactions (DGIs) and readmission rates (RAR). Retrospective sub-analysis of CYP-GUIDES data comprising CYP2D6
phenotypes was reclassified using standardized CYP2D6 genotype to phenotype
recommendations from the Clinical Pharmacogenetics Implementation Consortium
(CPIC) and Dutch Pharmacogenetics Working Group (DPWG).
Description
Keywords
Pharmaceutic, Pharmacology, Ethnicity, Race, Depression
Citation
Crutchley, R. D., & Keuler, N. (2022). Sub-analysis of cyp-guides data: Assessing the prevalence and impact of drug-gene interactions in an ethnically diverse cohort of depressed individuals. Frontiers in Pharmacology, 13, 884213. 10.3389/fphar.2022.884213