An in vitro study on the combination effect of metformin and n-acetyl cysteine against hyperglycaemia-induced cardiac damage

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dc.contributor.authorMabhida, Sihle E.
dc.date.accessioned2022-12-05T10:55:54Z
dc.date.available2022-12-05T10:55:54Z
dc.date.issued2019
dc.description.abstractChronic hyperglycaemia is a major risk factor for diabetes-induced cardiovascular dysfunction. In a hyperglycaemic state, excess production of reactive oxygen species (ROS), coupled with decreased levels of glutathione, contribute to increased lipid peroxidation and subsequent myocardial apoptosis. N-acetylcysteine (NAC) is a thiol-containing antioxidant known to protect against hyperglycaemic-induced oxidative stress by promoting the production of glutathioneen_US
dc.identifier.citationJohnson, Rabia, Nonhlakanipho F. Sangweni, Sihle E. Mabhida, Phiwayinkosi V. Dludla, Lawrence Mabasa, Sylvia Riedel, Charna Chapman, Rebamang A. Mosa, Abidemi P. Kappo, Johan Louw, and Christo J. F. Muller. 2019. "An In Vitro Study on the Combination Effect of Metformin and N-Acetyl Cysteine against Hyperglycaemia-Induced Cardiac Damage" Nutrients 11, no. 12: 2850. https://doi.org/10.3390/nu11122850en_US
dc.identifier.issn2072-6643
dc.identifier.urihttp://hdl.handle.net/10566/8234
dc.language.isoen_USen_US
dc.publisherMDPI - Publisher of Open Access Journalsen_US
dc.subjectoxidative stressen_US
dc.subjectdiabetesen_US
dc.subjectapoptosisen_US
dc.subjectN-acetyl cysteineen_US
dc.subjectmetforminen_US
dc.titleAn in vitro study on the combination effect of metformin and n-acetyl cysteine against hyperglycaemia-induced cardiac damageen_US
dc.typeArticleen_US

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