An in vitro study on the combination effect of metformin and n-acetyl cysteine against hyperglycaemia-induced cardiac damage
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Date
2019
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Publisher
MDPI - Publisher of Open Access Journals
Abstract
Chronic hyperglycaemia is a major risk factor for diabetes-induced cardiovascular dysfunction. In a hyperglycaemic state, excess production of reactive oxygen species (ROS), coupled with decreased levels of glutathione, contribute to increased lipid peroxidation and subsequent myocardial apoptosis. N-acetylcysteine (NAC) is a thiol-containing antioxidant known to protect against hyperglycaemic-induced oxidative stress by promoting the production of glutathione
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Keywords
oxidative stress, diabetes, apoptosis, N-acetyl cysteine, metformin
Citation
Johnson, Rabia, Nonhlakanipho F. Sangweni, Sihle E. Mabhida, Phiwayinkosi V. Dludla, Lawrence Mabasa, Sylvia Riedel, Charna Chapman, Rebamang A. Mosa, Abidemi P. Kappo, Johan Louw, and Christo J. F. Muller. 2019. "An In Vitro Study on the Combination Effect of Metformin and N-Acetyl Cysteine against Hyperglycaemia-Induced Cardiac Damage" Nutrients 11, no. 12: 2850. https://doi.org/10.3390/nu11122850