An investigation into combined amorphous form of sufadoxine, pyrimethamine and azithromycin

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dc.contributor.advisorAucamp, Marique
dc.contributor.authorOkello, Geoffrey
dc.date.accessioned2022-02-21T12:59:43Z
dc.date.accessioned2024-05-15T07:42:53Z
dc.date.available2024-05-15T07:42:53Z
dc.date.issued2021
dc.descriptionMagister Pharmaceuticae - MPharmen_US
dc.description.abstractMalaria remains one of the top mortality causes in the sub-Saharan African region, especially among pregnant women and infants. Despite several measures being implemented within the affected areas such as the use of treated mosquito nets, sulfadoxine and pyrimethamine (SULPYR) as an intermittent preventive treatment (IPTp-SP) is still considered the standard prophylactic regimen for pregnant women. Recently, the WHO increased the regimen of IPTp- SP from three to four doses on a monthly interval, this recommendation poses a potential risk of toxicity and resistance to the drugs. An improvement towards this challenge is under clinical trial and consists of the inclusion of azithromycin (AZI), a macrolide antibiotic, to the current IPTp-SP treatment regimen. This will not only aid in the prophylaxis of malaria in pregnant women but will also assist in other pregnancy related infections. All three these drugs exhibit poor aqueous solubility; requiring high concentrations for oral administration to achieve therapeutic plasma concentrations.en_US
dc.description.embargo2024
dc.identifier.urihttps://hdl.handle.net/10566/15155
dc.language.isoenen_US
dc.publisherUniversity of Western Capeen_US
dc.rights.holderUniversity of Western Capeen_US
dc.subjectMalariaen_US
dc.subjectsub-Saharan Africanen_US
dc.subjectPregnant womenen_US
dc.subjectDissolution rateen_US
dc.subjectSulfadoxineen_US
dc.titleAn investigation into combined amorphous form of sufadoxine, pyrimethamine and azithromycinen_US

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