Extension of the composite quality score (cqs) as an appraisal tool for prospective, controlled clinical therapy trials–A systematic review of meta-epidemiological evidence

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dc.contributor.authorMickenautsch, Steffen
dc.contributor.authorRupf, Stefan
dc.contributor.authorMiletić, Ivana
dc.date.accessioned2023-06-19T12:24:50Z
dc.date.available2023-06-19T12:24:50Z
dc.date.issued2022
dc.description.abstractTo conduct a survey of current meta-epidemiological studies to identify additional trial design characteristics that may be associated with significant over- or underestimation of the treatment effect and to use such identified characteristics as a basis for the formulation of new CQS appraisal criteria. We retrieved eligible studies from two systematic reviews on this topic (latest search May 2015) and searched the databases PubMed and Embase for further studies from June 2015 –March 2022. All data were extracted by one author and verified by another. Sufficiently homogeneous estimates from single studies were pooled using random-effects meta-analysis. Trial design characteristics associated with statistically significant estimates from single datasets (which could not be pooled) and meta-analyses were used as a basis to formulate new or amend existing CQS criteria.en_US
dc.identifier.citationMickenautsch, S. et al. (2022). Extension of the composite quality score (cqs) as an appraisal tool for prospective, controlled clinical therapy trials–A systematic review of meta-epidemiological evidence. PLoS ONE, 17(12), e0279645. https://doi. org/10.1371/journal.pone.0279645en_US
dc.identifier.issn1932-6203
dc.identifier.urihttps://doi.org/10.1371/journal.pone.0279645
dc.identifier.urihttp://hdl.handle.net/10566/9116
dc.language.isoenen_US
dc.publisherPublic Library of Scienceen_US
dc.subjectDatabase searchingen_US
dc.subjectClinical therapyen_US
dc.subjectRestorative dentistryen_US
dc.subjectMeta-epidemiologicalen_US
dc.titleExtension of the composite quality score (cqs) as an appraisal tool for prospective, controlled clinical therapy trials–A systematic review of meta-epidemiological evidenceen_US
dc.typeArticleen_US

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