Extension of the composite quality score (cqs) as an appraisal tool for prospective, controlled clinical therapy trials–A systematic review of meta-epidemiological evidence
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Date
2022
Journal Title
Journal ISSN
Volume Title
Publisher
Public Library of Science
Abstract
To conduct a survey of current meta-epidemiological studies to identify additional trial
design characteristics that may be associated with significant over- or underestimation of
the treatment effect and to use such identified characteristics as a basis for the formulation
of new CQS appraisal criteria. We retrieved eligible studies from two systematic reviews on this topic (latest search May
2015) and searched the databases PubMed and Embase for further studies from June 2015
–March 2022. All data were extracted by one author and verified by another. Sufficiently
homogeneous estimates from single studies were pooled using random-effects meta-analysis.
Trial design characteristics associated with statistically significant estimates from single
datasets (which could not be pooled) and meta-analyses were used as a basis to formulate
new or amend existing CQS criteria.
Description
Keywords
Database searching, Clinical therapy, Restorative dentistry, Meta-epidemiological
Citation
Mickenautsch, S. et al. (2022). Extension of the composite quality score (cqs) as an appraisal tool for prospective, controlled clinical therapy trials–A systematic review of meta-epidemiological evidence. PLoS ONE, 17(12), e0279645. https://doi. org/10.1371/journal.pone.0279645