Reconstruction of gene regulatory networks of inflammation-associated genes in different clinical stages of diffuse large B-cell lymphoma
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Date
2022
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
University of the Western Cape
Abstract
Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous malignancy
that is driven by complex gene regulatory networks (GRNs). Numerous genes exert
distinct effects on the progression and therapeutic outcome of DLBCL. Previous studies
have associated DLBCL with inflammation but the GRNs involved in this mechanism
have not yet been explored. The objectives of this current study are to reconstruct
inflammation-associated networks and to understand the effects of inflammation on
the pathogenesis and progression of DLBCL in different clinical stages.
Description
>Magister Scientiae - MSc
Keywords
Bioinformatics, Gene regulatory networks, B-cell lymphoma, Genes