Synthesis and evaluation of fluorescently linked polycyclic cage derivatives for application in neurodegenerative disorders
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Date
2020
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
University of the Western Cape
Abstract
Neurodegenerative diseases (ND) are chronic and progressive in nature, and
characterized by the gradual loss of neurons in various regions of the central
nervous system (CNS). ND include Alzheimer's disease (AD), Parkinson's disease
(PD), Huntington's disease (HD), multiple sclerosis (MS), amyotrophic lateral
sclerosis (ALS) and cerebral ischemia/reperfusion (CIR). They have various
progressive neurodegenerative pathologies that can result in several severe
functional impairments for patients, and ultimately lead to serious health-related
issues. According to more recent data, AD accounts for the most common cause of
dementia and is believed to contribute to approximately 60–70% of cases. AD is thus
seen as the most common form of dementia.
Description
Magister Pharmaceuticae - MPharm
Keywords
Neurodegeneration, Alzheimer’s disease, Parkinson`s Disease, Fluorescence, Pentacycloundecane