Synthesis of peptide-loaded chitosan nanoparticles for the treatment of sexually transmitted infections (STI’s)

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Date

2019

Journal Title

Journal ISSN

Volume Title

Publisher

University of Western Cape

Abstract

Peptides are among the main drugs which attract much attention because of their great potential in treating sexually transmitted diseases and other chronic diseases. There has been a major challenge of delivering these drugs in mucosal sites with low pH environment. The aim of this study is to synthesize acidic pH stable peptide loaded chitosan nanoparticles gels that could penetrate mucus layers covering the epithelial cells and kill HIV virus. Chitosan nanoparticles were synthesized by crosslinking method called Ionic gelation with Sodium tripolyphosphateTPP.

Description

>Magister Scientiae - MSc

Keywords

Chitosan, Microbicides, Tripolyphosphate, Poly acrylic acid, Antimicrobial activity

Citation