Pharmacological evaluation of antidiarrhoeal and antidiabetic activities of Syzygium Cordatum Hochst. ex C. Krauss

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dc.contributor.advisorAmabeoku, George J.
dc.contributor.authorDeliwe, Mzonke
dc.contributor.otherSchool of Pharmacy
dc.contributor.otherFaculty of Science
dc.date.accessioned2013-07-23T10:09:54Z
dc.date.accessioned2024-05-15T07:43:06Z
dc.date.available2012/10/25 15:14
dc.date.available2012/10/25
dc.date.available2013-07-23T10:09:54Z
dc.date.available2024-05-15T07:43:06Z
dc.date.issued2011
dc.descriptionMagister Pharmaceuticae - MPharmen_US
dc.description.abstractSyzygium cordatum is a medicinal plant indigenous to South Africa and Mozambique, commonly used to treat stomach aches, diabetes, respiratory problems and tuberculosis. In spite of the folklore use, adequate scientific data to credit its widespread traditional use is lacking. The objectives of this study were: to evaluate and validate scientifically the successful therapeutic claims by traditional medicine practitioners that Syzygium cordatum is effective in treating diarrhoea and diabetes; to determine the effects of the plant extract on gastrointestinal transit of a charcoal meal in mice; to determine the effects on castor oilinduced intestinal fluid accumulation; to determine the safety profile of the plant by carrying out acute toxicology study and to carry out preliminary screening of the active compounds present in the plant using standard phytochemical analytical procedures. The aqueous leaf extract of Syzygium cordatum (3.125 -50mg/kg, p.o) significantly reduced the faecal output caused by castor oil (0.7ml). All the doses used, reduced faecal output from 100% produced by castor oil to between 40 and 61%. S.cordatum (6.25 – 50mg/kg, p.o) significantly and in a dose dependent manner, delayed the onset of castor oil-induced diarrhoea.en_US
dc.description.countrySouth Africa
dc.identifier.urihttps://hdl.handle.net/10566/15189
dc.language.isoenen_US
dc.publisherUniversity of the Western Capeen_US
dc.rights.holderUniversity of the Western Capeen_US
dc.subjectSyzygium cordatumen_US
dc.subjectMyrtaceaeen_US
dc.subjectAntidiarrhoeal activityen_US
dc.subjectPharmacological evaluationen_US
dc.subjectAqueous leaf extracten_US
dc.subjectTraditional medicinesen_US
dc.subjectPhytochemical analysisen_US
dc.subjectMiceen_US
dc.subjectRatsen_US
dc.titlePharmacological evaluation of antidiarrhoeal and antidiabetic activities of Syzygium Cordatum Hochst. ex C. Kraussen_US
dc.typeThesisen_US

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