Oxidative stress and assisted reproduction: A comprehensive review of its pathophysiological role and strategies for optimizing embryo culture environment

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dc.contributor.authorAgarwal, Ashok
dc.contributor.authorRosas, Israel Maldonado
dc.contributor.authorHenkel, Ralf
dc.date.accessioned2022-09-19T09:27:50Z
dc.date.available2022-09-19T09:27:50Z
dc.date.issued2022
dc.description.abstractOxidative stress (OS) due to an imbalance between reactive oxygen species (ROS) and antioxidants has been established as an important factor that can negatively affect the outcomes of assisted reproductive techniques (ARTs). Excess ROS exert their pathological effects through damage to cellular lipids, organelles, and DNA, alteration of enzymatic function, and apoptosis. ROS can be produced intracellularly, from immature sperm, oocytes, and embryos. Additionally, several external factors may induce high ROS production in the ART setup, including atmospheric oxygen, CO2 incubators, consumables, visible light, temperature, humidity, volatile organic compounds, and culture media additives.en_US
dc.identifier.citationAgarwal, A. et al. (2022). Oxidative stress and assisted reproduction: A comprehensive review of its pathophysiological role and strategies for optimizing embryo culture environment. Antioxidants, 11(3), 477. https://doi.org/10.3390/antiox11030477en_US
dc.identifier.issn2076-3921
dc.identifier.urihttps://doi.org/10.3390/antiox11030477
dc.identifier.urihttp://hdl.handle.net/10566/7910
dc.language.isoenen_US
dc.publisherMDPIen_US
dc.subjectOxidative stressen_US
dc.subjectAntioxidantsen_US
dc.subjectCulture mediaen_US
dc.subjectEmbryo developmenten_US
dc.subjectFertilizationen_US
dc.titleOxidative stress and assisted reproduction: A comprehensive review of its pathophysiological role and strategies for optimizing embryo culture environmenten_US
dc.typeArticleen_US

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