Oxidative stress and assisted reproduction: A comprehensive review of its pathophysiological role and strategies for optimizing embryo culture environment
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Date
2022
Journal Title
Journal ISSN
Volume Title
Publisher
MDPI
Abstract
Oxidative stress (OS) due to an imbalance between reactive oxygen species (ROS) and
antioxidants has been established as an important factor that can negatively affect the outcomes
of assisted reproductive techniques (ARTs). Excess ROS exert their pathological effects through
damage to cellular lipids, organelles, and DNA, alteration of enzymatic function, and apoptosis.
ROS can be produced intracellularly, from immature sperm, oocytes, and embryos. Additionally,
several external factors may induce high ROS production in the ART setup, including atmospheric
oxygen, CO2 incubators, consumables, visible light, temperature, humidity, volatile organic compounds,
and culture media additives.
Description
Keywords
Oxidative stress, Antioxidants, Culture media, Embryo development, Fertilization
Citation
Agarwal, A. et al. (2022). Oxidative stress and assisted reproduction: A comprehensive review of its pathophysiological role and strategies for optimizing embryo culture environment. Antioxidants, 11(3), 477. https://doi.org/10.3390/antiox11030477