In-vitro cytotoxicity, anti-bacterial and anti-inflammatory activities of ecklonia radiata and jania verrucosa from Eastern Cape, South Africa

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dc.contributor.authorSaibu, Gbemisola M.
dc.contributor.authorOlawale, Fadaka O.
dc.contributor.authorMeyer, Mervin
dc.date.accessioned2025-01-21T07:47:19Z
dc.date.available2025-01-21T07:47:19Z
dc.date.issued2024
dc.description.abstractSeaweeds are marine floras constituting in part to over 90% of the oceanic biomass. Despite the enrichments of seaweeds, their potentials are largely unexplored. Hence, this study evaluated the phytochemical screening, antimicrobial, anti-inflammatory and cytotoxicity activities of methanolic extracts of Ecklonia radiata and Jania verrucosa. E. radiata and J. verrucosa were collected from sites on the rocky shores of the Mbashe and Port St. John rivers on the Eastern Cape coast of South Africa during spring low tides. Qualitative phytochemical screening was carried out using standard protocol. The assessment of anti-inflammatory activity was done by inhibition of albumin denaturation assay and antimicrobial analysis was performed against six different pathogenic clinical isolates. The cytotoxicity effect of the methanolic extracts were further investigated on MDA-MB-231, HepG2, CaCo-2 and KMST-6 by (3-(4,5-dimethylthiazol- 2-yl)-2,5-diphenyltetrazolium bromide) tetrazolium reduction assay (MTT assay).
dc.identifier.citationSaibu, G.M., Vincent, N.M., Omowunmi, O.A., Opeoluwa, O.O., Olawale, F.O. and Meyer, M., 2023. In-vitro Cytotoxicity, Anti-bacterial and Anti-inflammatory Activities of Ecklonia radiata and Jania verrucosa from Eastern Cape, South Africa. Tropical Journal of Natural Product Research, 7(1).
dc.identifier.urihttp://www.doi.org/10.26538/tjnpr/v7i1.6
dc.identifier.urihttps://hdl.handle.net/10566/19840
dc.language.isoen
dc.publisherFaculty of Pharmacy, University of Benin
dc.subjectSeaweeds
dc.subjectAnti-microbial
dc.subjectAnti-inflammatory
dc.subjectPhytochemical
dc.subjectAnti-cancer activity
dc.titleIn-vitro cytotoxicity, anti-bacterial and anti-inflammatory activities of ecklonia radiata and jania verrucosa from Eastern Cape, South Africa
dc.typeArticle

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