In-vitro cytotoxicity, anti-bacterial and anti-inflammatory activities of ecklonia radiata and jania verrucosa from Eastern Cape, South Africa
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Date
2024
Journal Title
Journal ISSN
Volume Title
Publisher
Faculty of Pharmacy, University of Benin
Abstract
Seaweeds are marine floras constituting in part to over 90% of the oceanic biomass. Despite the enrichments of seaweeds, their potentials are largely unexplored. Hence, this study evaluated the phytochemical screening, antimicrobial, anti-inflammatory and cytotoxicity activities of methanolic extracts of Ecklonia radiata and Jania verrucosa. E. radiata and J. verrucosa were collected from sites on the rocky shores of the Mbashe and Port St. John rivers on the Eastern Cape coast of South Africa during spring low tides. Qualitative phytochemical screening was carried out using standard protocol. The assessment of anti-inflammatory activity was done by inhibition of albumin denaturation assay and antimicrobial analysis was performed against six different pathogenic clinical isolates. The cytotoxicity effect of the methanolic extracts were further investigated on MDA-MB-231, HepG2, CaCo-2 and KMST-6 by (3-(4,5-dimethylthiazol- 2-yl)-2,5-diphenyltetrazolium bromide) tetrazolium reduction assay (MTT assay).
Description
Keywords
Seaweeds, Anti-microbial, Anti-inflammatory, Phytochemical, Anti-cancer activity
Citation
Saibu, G.M., Vincent, N.M., Omowunmi, O.A., Opeoluwa, O.O., Olawale, F.O. and Meyer, M., 2023. In-vitro Cytotoxicity, Anti-bacterial and Anti-inflammatory Activities of Ecklonia radiata and Jania verrucosa from Eastern Cape, South Africa. Tropical Journal of Natural Product Research, 7(1).