A novel nano therapeutic using convalescent plasma derived exosomal (CPExo) for Covid-19: A combined hyperactive immune modulation and diagnostics
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Date
2021
Journal Title
Journal ISSN
Volume Title
Publisher
Elsevier
Abstract
Extracellular vesicles like exosomes are important therapeutic tactics for treating COVID -19. By utilizing
convalescent plasma derived exosomes (CPExo) from COVID-19 recovered persistence could accelerate the
treatment strategies in the current state of affairs. Adequate literature has shown that administering the exosome
to the in vivo system could be beneficial and could target the pathogens in an effective and precise manner. In
this hypothesis we highlight the CPExo instead of convalescent plasma (CP), perhaps to dispense of exosomes are
gratified and it’s more effectively acquired immune response conferral through antibodies. COVID-19 convalescent plasma has billions of exosomes and it has aptitudes to carry molecular constituents like proteins, lipids,
RNA and DNA, etc. Moreover, exosomes are capable of recognizing antigens with adequate sensitivity and
specificity. Many of these derivatives could trigger an immune modulation into the cells and act as an epigenetic
inheritor response to target pathogens through RNAs. COIVID-19 resistance activated plasma-derived exosomes
are either responsible for the effects of plasma beyond the contained immune antibodies or could be inhibitory.
Description
Keywords
Exosomes, Convalescent plasma, Immunotherapy, Covid-19, Drugs
Citation
Anand, K. et al. (2021). A novel nano therapeutic using convalescent plasma derived exosomal (CPExo) for Covid-19: A combined hyperactive immune modulation and diagnostics. Chemico-Biological Interactions, 344, 109497. 10.1016/j.cbi.2021.109497