Response to letter to the Editor: The therapeutic strategy of drug re-positioning to induce autophagic cell death in brain malignancy
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Date
2021
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Springer Nature
Abstract
We thank Dr Yoshida for his valuable comments and interest in our study which describes the anti-cancer activity
of DS00329, a novel derivative of the anti-psychotic drug
phenothiazine, in glioblastoma multiforme (GBM) [1]. We
appreciate the information provided by Dr Yoshida that
illustrates that the activation of autophagy is an important
mechanism by which neurochemical compounds and dopamine receptor D4 antagonists inhibit GBM proliferation [2].
Furthermore, we agree with him that levels of p62/SQSTM1
is an important indicator of the autophagic state of cells
and that, in addition to our results showing an increase in
LC3-11, it would be important to determine the impact of
DS00329 on p62/SQSTM1 levels in glioblastoma cells.
Indeed, increased LC3‐II levels can be associated with either
enhanced autophagosome synthesis or reduced autophagosome turnover.
Description
Keywords
Apoptosis, Autophagic cell death, Brain neoplasms, Glioblastoma, Humans
Citation
Omoruyi, S.I. et al. (2021). Response to letter to the Editor: The therapeutic strategy of drug re-positioning to induce autophagic cell death in brain malignancy. Apoptosis, 26(1-2), pp. 2-3