Response to letter to the Editor: The therapeutic strategy of drug re-positioning to induce autophagic cell death in brain malignancy

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dc.contributor.authorOmoruyi, S.I
dc.contributor.authorJardine, A
dc.contributor.authorPrince, S
dc.date.accessioned2021-05-31T09:01:43Z
dc.date.available2021-05-31T09:01:43Z
dc.date.issued2021
dc.description.abstractWe thank Dr Yoshida for his valuable comments and interest in our study which describes the anti-cancer activity of DS00329, a novel derivative of the anti-psychotic drug phenothiazine, in glioblastoma multiforme (GBM) [1]. We appreciate the information provided by Dr Yoshida that illustrates that the activation of autophagy is an important mechanism by which neurochemical compounds and dopamine receptor D4 antagonists inhibit GBM proliferation [2]. Furthermore, we agree with him that levels of p62/SQSTM1 is an important indicator of the autophagic state of cells and that, in addition to our results showing an increase in LC3-11, it would be important to determine the impact of DS00329 on p62/SQSTM1 levels in glioblastoma cells. Indeed, increased LC3‐II levels can be associated with either enhanced autophagosome synthesis or reduced autophagosome turnover.en_US
dc.identifier.citationOmoruyi, S.I. et al. (2021). Response to letter to the Editor: The therapeutic strategy of drug re-positioning to induce autophagic cell death in brain malignancy. Apoptosis, 26(1-2), pp. 2-3en_US
dc.identifier.issn13608185
dc.identifier.uri10.1007/s10495-020-01646-w
dc.identifier.urihttp://hdl.handle.net/10566/6225
dc.language.isoenen_US
dc.publisherSpringer Natureen_US
dc.subjectApoptosisen_US
dc.subjectAutophagic cell deathen_US
dc.subjectBrain neoplasmsen_US
dc.subjectGlioblastomaen_US
dc.subjectHumansen_US
dc.titleResponse to letter to the Editor: The therapeutic strategy of drug re-positioning to induce autophagic cell death in brain malignancyen_US
dc.typeArticleen_US

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