Investigation of bioactive compounds in Crassocephalum rubens leaf and in vitro anticancer activity of its biosynthesized gold nanoparticles
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Date
2020
Journal Title
Journal ISSN
Volume Title
Publisher
Elsevier
Abstract
The development of cancer therapies has become difficult due to high metastasis, and lack of tissue
selectivity, which in most cases affects normal cells. Demand for anticancer therapy is therefore
increasing on daily basis. Gold nanoparticles (AuNPs) have many applications in biomedical field.
Biological synthesis of AuNPs using aqueous extract of Crassocephalum rubens (AECR) was designed to
investigate the in vitro anticancer potential. The synthesized AuNPs were characterized by UV–vis
spectroscopy, high-resolution transmission electron microscopy, and Fourier transform infrared
spectroscopy. The characterization results showed the formation of green AuNPs of wavelength
538 nm, and mostly spherical AuNPs with 20 5 nm size. Significant anticancer activity of the AECRAuNPs on MCF-7 and Caco-2 cells was noted at higher concentrations (125 and 250mg/mL) during 24 and
at all concentrations tested during 48 h. It can therefore be concluded that AECR leaves can mediate stable
AuNPs with anticancer properties.
Description
Keywords
Crassocephalum rubens, Bioactive compounds, Breast cancer, Colorectal cancer, Gold nanoparticles
Citation
Roux, S. et al. (2020). Investigation of bioactive compounds in Crassocephalum rubens leaf and in vitro anticancer activity of its biosynthesized gold nanoparticles. Biotechnology Reports ,28,e00560