Investigation of bioactive compounds in Crassocephalum rubens leaf and in vitro anticancer activity of its biosynthesized gold nanoparticles

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dc.contributor.authorRoux, Saartjie
dc.contributor.authorAdewale, Olusola Bolaji
dc.contributor.authorPotts-Johnson, Sotonye S.
dc.date.accessioned2020-12-11T07:28:33Z
dc.date.available2020-12-11T07:28:33Z
dc.date.issued2020
dc.description.abstractThe development of cancer therapies has become difficult due to high metastasis, and lack of tissue selectivity, which in most cases affects normal cells. Demand for anticancer therapy is therefore increasing on daily basis. Gold nanoparticles (AuNPs) have many applications in biomedical field. Biological synthesis of AuNPs using aqueous extract of Crassocephalum rubens (AECR) was designed to investigate the in vitro anticancer potential. The synthesized AuNPs were characterized by UV–vis spectroscopy, high-resolution transmission electron microscopy, and Fourier transform infrared spectroscopy. The characterization results showed the formation of green AuNPs of wavelength 538 nm, and mostly spherical AuNPs with 20 5 nm size. Significant anticancer activity of the AECRAuNPs on MCF-7 and Caco-2 cells was noted at higher concentrations (125 and 250mg/mL) during 24 and at all concentrations tested during 48 h. It can therefore be concluded that AECR leaves can mediate stable AuNPs with anticancer properties.en_US
dc.identifier.citationRoux, S. et al. (2020). Investigation of bioactive compounds in Crassocephalum rubens leaf and in vitro anticancer activity of its biosynthesized gold nanoparticles. Biotechnology Reports ,28,e00560en_US
dc.identifier.issn2215-017X
dc.identifier.urihttps://doi.org/10.1016/j.btre.2020.e00560
dc.identifier.urihttp://hdl.handle.net/10566/5500
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.subjectCrassocephalum rubensen_US
dc.subjectBioactive compoundsen_US
dc.subjectBreast canceren_US
dc.subjectColorectal canceren_US
dc.subjectGold nanoparticlesen_US
dc.titleInvestigation of bioactive compounds in Crassocephalum rubens leaf and in vitro anticancer activity of its biosynthesized gold nanoparticlesen_US
dc.typeArticleen_US

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