Transient transgene expression of human Coronavirus nl63 orf3 protein in a baculovirus system
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Date
2020
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
University of Western Cape
Abstract
Insect-derived baculoviruses have been used extensively as a safe and versatile research model for transgenic protein expression. Preclinical studies have revealed the promising potential of Baculoviruses as a delivery vector for a variety of therapeutic applications, including vaccination, tissue engineering and cancer treatments. Coronaviruses are enveloped viruses containing linear, non-segmented ribonucleic acid. Human coronavirus NL63 was first discovered in the Netherlands in January 2004, where a 7-month-old girl presented with an acute respiratory tract infection that was later established to predominantly infect infants, the elderly and immunocompromised individuals.
Description
Magister Scientiae (Medical Bioscience) - MSc(MBS)
Keywords
Human Coronavirus, Baculovirus system, Transgenic protein expression, Viruses, Bacterial cell lines