Differentially expressed serum proteins from obese Wistar rats as a risk factor for obesity-induced diseases
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Date
2020
Journal Title
Journal ISSN
Volume Title
Publisher
Springer Nature
Abstract
Obesity is a chronic disease that negatively affects life expectancy through its association with life-threatening diseases such as cancer and cardiovascular diseases. Expression proteomics combined with in silico interaction studies are used to uncover potential biomarkers and the pathways that promote obesity-related complications. These biomarkers can either aid in the development of personalized therapies or identify individuals at risk of developing obesity-related diseases. To determine the serum protein changes, Wistar rats were fed standard chow (low fat, LF), or chow formulated high fat (HF) diets (HF1, HF2 and HF3) for 8 and 42 weeks to induce obesity. Serum samples were collected from lean and obese rats at these time points.
Description
Keywords
Computational biology and bioinformatics, Biomarkers, Obesity, Wistar rats, Serum protein
Citation
Gabuza, K. B. et al. (2020) .Differentially expressed serum proteins from obese Wistar rats as a risk factor for obesity-induced diseases. Scientific Reports,10(1),12415