Synthesis, computational and biological studies of alkyltin(IV) N-methyl-N-hydroxyethyl dithiocarbamate complexes

dc.contributor.authorAdeyemi, Jerry O.
dc.contributor.authorSaibu, Gbemisola M.
dc.contributor.authorFadaka, Adewale O.
dc.date.accessioned2021-10-07T11:10:34Z
dc.date.available2021-10-07T11:10:34Z
dc.date.issued2021
dc.description.abstractMethyltin(IV) of butyltin(IV)–N-hydroxyethyl dithiocarbamate complexes, represented as [(CH3)2Sn(L(OH))2] and [(C4H9)2Sn(L(OH))2] respectively were synthesized and characterized using spectroscopic techniques (1 H, 13C and 119Sn NMR) and elemental analysis. Both infrared and NMR data showed that, the complexes were formed via two sulphur atoms of the dithiocarbamate group. This mode of coordination was further supported by the DFT calculation, which suggested the formation of a distorted octahedral geometry around the tin atom. The complexes were screened for their antioxidant, cytotoxicity and anti-inflammatory properties. Four different assays including DPPH, nitric oxide, reducing power and hydrogen peroxides were used for the antioxidant studies, while an in vitro anti-inflammatory study was done using albumin denaturation assay. The complexes showed good antioxidant activity, especially in the DPPH assay. Butyltin(IV)–N-hydroxyethyl dithiocarbamate showed better cytotoxicity activity compared to methyltin(IV)–N-hydroxyethyl dithiocarbamate in the selected cell lines, which included KMST-6, Caco-2 and A549 cell lines. The anti-inflammatory activities revealed that the two complexes have useful activities better than diclofenac used as control drug.en_US
dc.identifier.citationAdeyemi, J. O. et al. (2021). Synthesis, computational and biological studies of alkyltin(IV) N-methyl-N-hydroxyethyl dithiocarbamate complexes. Heliyon, 7(8), e07693. https://doi.org/10.1016/j.heliyon.2021.e07693en_US
dc.identifier.issn2405-8440
dc.identifier.urihttps://doi.org/10.1016/j.heliyon.2021.e07693
dc.identifier.urihttp://hdl.handle.net/10566/6867
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.subjectAntioxidanten_US
dc.subjectAnti-inflammatoryen_US
dc.subjectOrganotinen_US
dc.subjectBiotechnologyen_US
dc.titleSynthesis, computational and biological studies of alkyltin(IV) N-methyl-N-hydroxyethyl dithiocarbamate complexesen_US
dc.typeArticleen_US

Files

Original bundle
Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
1-s2.0-S2405844021017965-main.pdf
Size:
1.82 MB
Format:
Adobe Portable Document Format
Description:
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description: