Synthesis, computational and biological studies of alkyltin(IV) N-methyl-N-hydroxyethyl dithiocarbamate complexes
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Date
2021
Journal Title
Journal ISSN
Volume Title
Publisher
Elsevier
Abstract
Methyltin(IV) of butyltin(IV)–N-hydroxyethyl dithiocarbamate complexes, represented as [(CH3)2Sn(L(OH))2]
and [(C4H9)2Sn(L(OH))2] respectively were synthesized and characterized using spectroscopic techniques (1
H, 13C and 119Sn NMR) and elemental analysis. Both infrared and NMR data showed that, the complexes were
formed via two sulphur atoms of the dithiocarbamate group. This mode of coordination was further supported by
the DFT calculation, which suggested the formation of a distorted octahedral geometry around the tin atom. The
complexes were screened for their antioxidant, cytotoxicity and anti-inflammatory properties. Four different
assays including DPPH, nitric oxide, reducing power and hydrogen peroxides were used for the antioxidant
studies, while an in vitro anti-inflammatory study was done using albumin denaturation assay. The complexes
showed good antioxidant activity, especially in the DPPH assay. Butyltin(IV)–N-hydroxyethyl dithiocarbamate
showed better cytotoxicity activity compared to methyltin(IV)–N-hydroxyethyl dithiocarbamate in the selected
cell lines, which included KMST-6, Caco-2 and A549 cell lines. The anti-inflammatory activities revealed that the
two complexes have useful activities better than diclofenac used as control drug.
Description
Keywords
Antioxidant, Anti-inflammatory, Organotin, Biotechnology
Citation
Adeyemi, J. O. et al. (2021). Synthesis, computational and biological studies of alkyltin(IV) N-methyl-N-hydroxyethyl dithiocarbamate complexes. Heliyon, 7(8), e07693. https://doi.org/10.1016/j.heliyon.2021.e07693