Investigation of the coordination chemistry, biomolecular interactions, and cytotoxicity of heterocyclic carboxamide manganese(II) complexes

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dc.contributor.authorMoabelo Koena
dc.contributor.authorMeyer Mervin
dc.contributor.authorTsaulwayo Nokwanda
dc.contributor.authorXulu Bheki
dc.date.accessioned2025-09-04T17:34:18Z
dc.date.available2025-09-04T17:34:18Z
dc.date.issued2025
dc.description.abstractFor the past few decades, platinum-based compounds notably cisplatin have been the most commonly used in metal-based anti-cancer treatment.[1,2] Despite the success of cisplatin, it has several drawbacks such as side effects, poor solubility, and acquired drug resistance, thus limiting its efficacy. [3,4] These negative attributes of cisplatin have germinated research interests in the design and development of alternative nonplatinum metallo-drugs such as ruthenium, iridium, osmium, palladium, and manganese. [5–7] Compared to the extensive reports on noble metals such as ruthenium and palladium, there are few reports on these of manganese compounds as anticancer agents. [8]
dc.identifier.citationTsaulwayo, N., Moabelo, K. L., Meyer, M., & Ojwach, S. O. (2025). Investigation of the coordination chemistry, biomolecular interactions and cytotoxicity of heterocyclic carboxamide manganese(II) complexes. European Journal of Inorganic Chemistry. https://doi.org/10.1002/ejic.202500234
dc.identifier.urihttps://hdl.handle.net/10566/20834
dc.language.isoen
dc.publisherWiley-VCH GmbH
dc.subjectReactions of ligands 5-methyl-N
dc.subjectN-(N-(pyridin-2-ylmethyl)pyrazine-2-carboxamide
dc.subjectN-(quinolin-8-yl)picolinamide
dc.subjectN-(quinolin-8-yl)quinoline-2-carboxamide
dc.subjectSolid state structures
dc.titleInvestigation of the coordination chemistry, biomolecular interactions, and cytotoxicity of heterocyclic carboxamide manganese(II) complexes
dc.typeArticle

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