Inhibition of HIV-1 enzymes, antioxidant and anti-inflammatory activities of Plectranthus barbatus

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dc.contributor.authorKapewangolo, Petrina
dc.contributor.authorHussein, Ahmed A.
dc.contributor.authorMeyer, Debra
dc.date.accessioned2023-06-28T08:52:05Z
dc.date.available2023-06-28T08:52:05Z
dc.date.issued213
dc.description.abstractEthnopharmacological relevance: Plectranthus barbatus is widely used in African countries as an herbal remedy to manage HIV/AIDS and related conditions. Aim of the study: To investigate the HIV-1 inhibitory, anti-inflammatory and antioxidant properties of P. barbatus and thereby provide empirical evidence for the apparent anecdotal success of the extracts. Materials and methods: Ethanolic extract of P. barbatus's leaves was screened against two HIV-1 enzymes: protease (PR) and reverse transcriptase (RT). Cytotoxicity of the extract was determined through measuring tetrazolium dye uptake of peripheral blood mononuclear cells (PBMCs) and the TZM-bl cell line. Confirmatory assays for cytotoxicity were performed using flow cytometry and real-time cell electronic sensing (RT-CES). The free radical scavenging activity of the extract was investigated with 2,2- diphenyl-1-picrylhydrazyl while the anti-inflammatory properties of the plant extract were investigated using a Th1/Th2/Th17 cytometric bead array technique.en_US
dc.identifier.citationKapewangolo, P. et al. (2015). Inhibition of HIV-1 enzymes, antioxidant and anti-inflammatory activities of Plectranthus barbatus. Journal of Ethnopharmacology, 149(1),184-190. https://doi.org/10.1016/j.jep.2013.06.019en_US
dc.identifier.issn0378-8741
dc.identifier.urihttps://doi.org/10.1016/j.jep.2013.06.019
dc.identifier.urihttp://hdl.handle.net/10566/9171
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.subjectChemistryen_US
dc.subjectHIV-1 proteaseen_US
dc.subjectPublic healthen_US
dc.subjectPlectranthus barbatusen_US
dc.titleInhibition of HIV-1 enzymes, antioxidant and anti-inflammatory activities of Plectranthus barbatusen_US
dc.typeArticleen_US

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