The combat-tb workbench: Making powerful Mycobacterium tuberculosis bioinformatics accessible

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Date

2022

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Publisher

American Society for Microbiology

Abstract

Whole-genome sequencing (WGS) is a powerful method for detecting drug resistance, genetic diversity, and transmission dynamics of Mycobacterium tuberculosis. Implementation of WGS in public health microbiology laboratories is impeded by a lack of user-friendly, automated, and semiautomated pipelines. We present the COMBAT-TB Workbench, a modular, easy-to-install application that provides a web-based environment for Mycobacterium tuberculosis bioinformatics. The COMBAT-TB Workbench is built using two main software components: the IRIDA platform for its web-based user interface and data management capabilities and the Galaxy bioinformatics workflow platform for workflow execution.

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Keywords

Mycobacterium tuberculosis, Bioinformatics, Tuberculosis, Biology

Citation

van Heusden, P. et al. (2022). The combat-tb workbench: Making powerful mycobacterium Tuberculosis bioinformatics accessible. mSphere, 7(1), e00991-21. https://doi.org/10.1128/msphere.00991-21

URI

https://doi.org/10.1128/msphere.00991-21
 http://hdl.handle.net/10566/7914

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Research Articles (SANBI)