Prospects of using gum Arabic silver nanoparticles in toothpaste to prevent dental caries

Simple item page
dc.contributor.authorAhmed, Omnia Abdelmoneim Khidir
dc.contributor.authorSibuyi, Nicole Remaliah Samantha
dc.contributor.authorFadaka, Adewale Oluwaseun
dc.date.accessioned2023-04-18T08:53:25Z
dc.date.available2023-04-18T08:53:25Z
dc.date.issued2023
dc.description.abstractThere is growing interest in the use of green synthesized silver nanoparticles (AgNPs) to control and prevent dental diseases. The incorporation of green synthesized AgNPs into dentifrices to reduce pathogenic oral microbes is motivated by their presumed biocompatibility and broad-spectrum antimicrobial activity. In the present study, gum arabic AgNPs (GA-AgNPs) were formulated into a toothpaste (TP) using a commercial TP at a non-active concentration, to produce GA-AgNPs_TP. The TP was selected after evaluating the antimicrobial activity of four commercial TPs 1-4 on selected oral microbes using agar disc diffusion and microdilution assays. The less active TP-1 was then used in the formulation of GA-AgNPs_TP-1; thereafter, the antimicrobial activity of GA-AgNPs_0.4g was compared to GA-AgNPs_TP-1. The cytotoxicity of GA-AgNPs_0.4g and GA-AgNPs_TP-1 was also assessed on the buccal mucosa fibroblast (BMF) cells using the MTT assay. The study demonstrated that antimicrobial activity of GA-AgNPs_0.4g was retained after being combined with a sub-lethal or inactive concentration of TP-1.en_US
dc.identifier.citationAhmed, O. A. K. et al. (2023). Prospects of using gum Arabic silver nanoparticles in toothpaste to prevent dental caries. Pharmaceutics, 15(3), 871. https://doi.org/10.3390/pharmaceutics15030871en_US
dc.identifier.issn1999-4923
dc.identifier.urihttps://doi.org/10.3390/pharmaceutics15030871
dc.identifier.urihttp://hdl.handle.net/10566/8825
dc.language.isoenen_US
dc.publisherMDPIen_US
dc.subjectGreen synthesisen_US
dc.subjectGum Arabicen_US
dc.subjectSilver nanoparticlesen_US
dc.subjectAraben_US
dc.subjectAntimicrobialen_US
dc.titleProspects of using gum Arabic silver nanoparticles in toothpaste to prevent dental cariesen_US
dc.typeArticleen_US

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
ahmed_prospects of using gum arabic_2023.pdf
Size:
807.95 KB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

Research Articles (Biotechnology)