Prospects of using gum Arabic silver nanoparticles in toothpaste to prevent dental caries
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Date
2023
Journal Title
Journal ISSN
Volume Title
Publisher
MDPI
Abstract
There is growing interest in the use of green synthesized silver nanoparticles (AgNPs) to
control and prevent dental diseases. The incorporation of green synthesized AgNPs into dentifrices to
reduce pathogenic oral microbes is motivated by their presumed biocompatibility and broad-spectrum
antimicrobial activity. In the present study, gum arabic AgNPs (GA-AgNPs) were formulated into a
toothpaste (TP) using a commercial TP at a non-active concentration, to produce GA-AgNPs_TP. The
TP was selected after evaluating the antimicrobial activity of four commercial TPs 1-4 on selected oral
microbes using agar disc diffusion and microdilution assays. The less active TP-1 was then used in
the formulation of GA-AgNPs_TP-1; thereafter, the antimicrobial activity of GA-AgNPs_0.4g was
compared to GA-AgNPs_TP-1. The cytotoxicity of GA-AgNPs_0.4g and GA-AgNPs_TP-1 was also
assessed on the buccal mucosa fibroblast (BMF) cells using the MTT assay. The study demonstrated
that antimicrobial activity of GA-AgNPs_0.4g was retained after being combined with a sub-lethal
or inactive concentration of TP-1.
Description
Keywords
Green synthesis, Gum Arabic, Silver nanoparticles, Arab, Antimicrobial
Citation
Ahmed, O. A. K. et al. (2023). Prospects of using gum Arabic silver nanoparticles in toothpaste to prevent dental caries. Pharmaceutics, 15(3), 871. https://doi.org/10.3390/pharmaceutics15030871