Computational characterization of iron metabolism in the tsetse disease vector, glossina morsitans: Ire stem-loops

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dc.contributor.authorDashti, Zahra Jalali Sefid
dc.contributor.authorGamieldien, Junaid
dc.contributor.authorChristoffels, Alan
dc.date.accessioned2023-06-02T10:08:15Z
dc.date.available2023-06-02T10:08:15Z
dc.date.issued2016
dc.description.abstractIron metabolism and regulation is an indispensable part of species survival, most importantly for blood feeding insects. Iron regulatory proteins are central regulators of iron homeostasis, whose binding to iron response element (IRE) stem-loop structures within the UTRs of genes regulate expression at the post-transcriptional level. Despite the extensive literature on themechanism of iron regulation in human, less attention has been given to insect and more specifically the blood feeding insects, where research has mainly focused on the characterization of ferritin and transferrin. We thus, examined the mechanism of iron homeostasis through a genome-wide computational identification of IREs and other enriched motifs in the UTRs of Glossina morsitans with the view to identify new IRE-regulated genes.en_US
dc.identifier.citationDashti, Z. J.S. et al. (2016). Computational characterization of iron metabolism in the tsetse disease vector, glossina morsitans: Ire stem-loops. BMC Genomics, 17, 561. https://doi.org/10.1186/s12864-016-2932-7en_US
dc.identifier.issn1471-2164
dc.identifier.urihttps://doi.org/10.1186/s12864-016-2932-7
dc.identifier.urihttp://hdl.handle.net/10566/8997
dc.language.isoenen_US
dc.publisherBMCen_US
dc.subjectBioinformaticsen_US
dc.subjectHematophagyen_US
dc.subjectGlossina morsitansen_US
dc.subjectIron metabolismen_US
dc.titleComputational characterization of iron metabolism in the tsetse disease vector, glossina morsitans: Ire stem-loopsen_US
dc.typeArticleen_US

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