The design and evaluation of ciprofloxacin-loaded nanoformulations using Ipomoea batatas starch nanoparticles
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Date
2023
Journal Title
Journal ISSN
Volume Title
Publisher
SpringerOpen
Abstract
Starch nanoparticle derivatives are gaining popularity as drug delivery vehicles because of their biocompatibility,
better mechanical characteristics, heat stability properties, impediment qualities, permeability capabilities,
and flexibility to be changed for specific predetermined functions. The effect of techniques and processing time
on the physiochemical and drug release characteristics of sweet potato (Ipomoea batatas) starch nanoparticles and
their ciprofloxacin-loaded nanoformulations was studied. Scanning electron microscopy confirmed that the treated starch formed nanoparticles and also revealed
significant changes in the morphology of the treated starches. The water absorption capacity of chemically treated
starch nanoparticles (CTSN)-3 days was the highest, whereas CTSN-6 days had the maximum solubility. The functional
groups present in the starch nanoparticles were confirmed by Fourier transform infrared spectroscopy and Raman.
The thermal characteristics of starch nanoparticles were established using hot-stage microscopy, differential scanning
calorimetry, and thermogravimetric analysis.
Description
Keywords
Pharmacology, Starch nanoparticle, Drug release studies, Nanotechnology, Physiological chemistry
Citation
Ajala, T. O. et al. (2023). The design and evaluation of ciprofloxacin-loaded nanoformulations using Ipomoea batatas starch nanoparticles. Future Journal of Pharmaceutical Sciences, 9, 37. https://doi.org/10.1186/s43094-023-00487-z