Understanding human coronavirus HCoV-NL63
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Date
2010
Journal Title
Journal ISSN
Volume Title
Publisher
Bentham Science
Abstract
Even though coronavirus infection of humans is not normally associated with severe diseases, the identification
of the coronavirus responsible for the outbreak of severe acute respiratory syndrome showed that highly pathogenic
coronaviruses can enter the human population. Shortly thereafter, in Holland in 2004, another novel human coronavirus
(HCoV-NL63) was isolated from a seven-month old infant suffering from respiratory symptoms. This virus has
subsequently been identified in various countries, indicating a worldwide distribution. HCoV-NL63 has been shown to
infect mainly children and the immunocommpromised, who presented with either mild upper respiratory symptoms
(cough, fever and rhinorrhoea) or more serious lower respiratory tract involvement such as bronchiolitis and croup, which
was observed mainly in younger children. In fact, HCoV-NL63 is the aetiological agent for up to 10% of all respiratory
diseases. This review summarizes recent findings of human coronavirus HCoV-NL63 infections, including isolation and
identification, phylogeny and taxonomy, genome structure and transcriptional regulation, transmission and pathogenesis,
and detection and diagnosis.
Description
Clinical features
Pathogenesis
Diagnosis
Pathogenesis
Diagnosis
Keywords
Human coronavirus HCOV-NL63
Citation
Abdul-Rasool, S. and Fielding, B.( 2010). Understanding human coronavirus HCoV-NL63. The Open Virology Journal, 4: 42-50