A comparison of susceptibility patterns of oral Candida isolates from South African and Cameroonian HIV- positive populations

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dc.contributor.authorAbrantes, Pedro Miguel dos Santos
dc.contributor.authorMcArthur, Carole P.
dc.contributor.authorAfrica, Charlene W.J.
dc.date.accessioned2014-07-30T13:24:57Z
dc.date.available2014-07-30T13:24:57Z
dc.date.issued2012
dc.descriptionAn oral presentation was presented at the 90th General Session & Exhibition of the IADR, 20-23 June 2012, Iguaçu Falls, Brazil. Only the abstract was published.
dc.description.abstractMETHOD: In this study, Candida isolates were collected from the oral mucosa of 128 South African and 126 Cameroonian HIV-positive patients, by scraping the mouths of consenting patients using sterile cotton swabs. Ethics clearance for this project was granted by the University of the Western Cape. Confirmation of Candida species was done by growth on differential media, Gram staining and microscopy. The isolates were grown on selective media and differentiated using two commercial chromogenic agars and Tomato (V8) agar. Changes in colony colour, morphology and pseudohyphae/chlamydospore expression could then be observed, allowing for species differentiation. Isolates were also examined for antifungal susceptibility patterns using the TREK system. RESULT: The results from this study suggest that the prevalence of Candida species varies according to geographical region and HIV-subtype. Discrepancies in antifungal drug susceptibility patterns were also observed in the two populations. CONCLUSION: The emerging drug-resistance raises the need for increased species prevalence surveillance, as this information can have clinical implications in the choice of more appropriate and effective patient treatment.en_US
dc.description.sponsorshipNational Research Foundation of South Africaen_US
dc.identifier.citationAbrantes, P.M.D.S., McArthur, C.P. & Africa, C.W.J. (2012). A comparison of susceptibility patterns of oral Candida isolates from South African and Cameroonian HIV- positive populations. International Association for Dental Research 90th General Session, At Iguaçu Falls, Brazil, Volume: Journal of Dental Research 91(Spec Issue B): 35;138en_US
dc.identifier.urihttp://hdl.handle.net/10566/1139
dc.identifier.urihttps://iadr.confex.com/iadr/2012rio/webprogram/Paper163723.html
dc.language.isoenen_US
dc.privacy.showsubmitterfalse
dc.publisherThe International Association for Dental Research (IADR)en_US
dc.rightsThis file may be freely used for educational uses, as long as it is not altered in any way. No commercial reproduction or distribution of this file is permitted without written permission of the authors.
dc.status.ispeerreviewedtrue
dc.subjectCandidaen_US
dc.subjectAfricaen_US
dc.subjectfluconazoleen_US
dc.titleA comparison of susceptibility patterns of oral Candida isolates from South African and Cameroonian HIV- positive populationsen_US
dc.typeOtheren_US

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