Fabrication of type-I indium-based near-infrared emitting quantum dots for biological imaging applications
| dc.contributor.advisor | Onani, Martin | |
| dc.contributor.advisor | Madiehe, Abraham | |
| dc.contributor.author | Mushonga, Paul | |
| dc.date.accessioned | 2021-06-29T10:05:56Z | |
| dc.date.accessioned | 2024-05-13T12:40:29Z | |
| dc.date.available | 2021-06-29T10:05:56Z | |
| dc.date.available | 2024-05-13T12:40:29Z | |
| dc.date.issued | 2013 | |
| dc.description | Doctor Scientiae - DSc | en_US |
| dc.description.abstract | Semiconductor nanocrystals or quantum dots (QDs) are fluorescent nanometer-sized particles which have physical dimensions that are smaller than the excitonic Bohr radius, large surface area-to-volume ratios, broad absorption spectra and very large molar extinction coefficients. Biomedical applications of QDs are mainly based on II-VI QDs containing cadmium, such as CdSe/ZnS. These cadmium-based systems are associated with high toxicity due to cadmium. As a result, potential replacements of cadmium-based QDs in biological applications are needed. In this study, InP/ZnSe QDs were synthesized for the first time using a one-pot hot injection method. Furthermore, a growth-doping method was used for silver, cobalt and iron incorporation into the InP core. Water compatibility was achieved through ligand exchange with 3- mercaptopropionic acid. In vitro cytotoxicity and imaging/internalization of the as-prepared MP A-InP/ZnSe and MP A-capped CdTe/ZnS QDs were evaluated. InP/ZnSe QDs were successfully synthesized with ZnSe shell causing a 1.4 times reduction in trap-related emission. | en_US |
| dc.identifier.uri | https://hdl.handle.net/10566/14692 | |
| dc.language.iso | en | en_US |
| dc.publisher | University of the Western Cape | en_US |
| dc.rights.holder | University of the Western Cape | en_US |
| dc.subject | Nanocrystal | en_US |
| dc.subject | Quantum dots | en_US |
| dc.subject | Biomedical applications | en_US |
| dc.subject | Iron incorporation | en_US |
| dc.title | Fabrication of type-I indium-based near-infrared emitting quantum dots for biological imaging applications | en_US |