Single nucleotide polymorphisms in amlodipine-associated genes and their correlation with blood pressure control among South African adults with hypertension

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Date

2022

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MDPI

Abstract

This study describes the single nucleotide polymorphisms (SNPs) in amlodipineassociated genes and assesses their correlation with blood pressure control among South African adults with hypertension. Methods: In total, 304 hypertensive patients on amlodipine treatment belonging to the indigenous Swati, Xhosa and Zulu population groups of South Africa were recruited between June 2017 and June 2019. Participants were categorized into: controlled (blood pressure < 140/90 mmHg) and uncontrolled (blood pressure 140/90 mmHg) hypertension. Thirteen SNPs in amlodipine pharmacogenes with a high PharmGKB evidence base were selected and genotyped using MassArray (Agena BioscienceTM).

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Keywords

Amlodipine, Nucleotide polymorphisms, Blood pressure, Hypertension, South Africa

Citation

Masilela, C. et al. (2022). Single nucleotide polymorphisms in amlodipine-associated genes and their correlation with blood pressure control among South African adults with hypertension. Genes, 13(8), 1394. https://doi.org/10.3390/genes13081394

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https://doi.org/10.3390/genes13081394
 http://hdl.handle.net/10566/7813

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Research Articles (Biotechnology)