Single nucleotide polymorphisms in amlodipine-associated genes and their correlation with blood pressure control among South African adults with hypertension

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dc.contributor.authorMasilela, Charity
dc.contributor.authorAdeniyi, Oladele Vincent
dc.contributor.authorBenjeddou, Mongi
dc.date.accessioned2022-09-06T09:41:43Z
dc.date.available2022-09-06T09:41:43Z
dc.date.issued2022
dc.description.abstractThis study describes the single nucleotide polymorphisms (SNPs) in amlodipineassociated genes and assesses their correlation with blood pressure control among South African adults with hypertension. Methods: In total, 304 hypertensive patients on amlodipine treatment belonging to the indigenous Swati, Xhosa and Zulu population groups of South Africa were recruited between June 2017 and June 2019. Participants were categorized into: controlled (blood pressure < 140/90 mmHg) and uncontrolled (blood pressure 140/90 mmHg) hypertension. Thirteen SNPs in amlodipine pharmacogenes with a high PharmGKB evidence base were selected and genotyped using MassArray (Agena BioscienceTM).en_US
dc.identifier.citationMasilela, C. et al. (2022). Single nucleotide polymorphisms in amlodipine-associated genes and their correlation with blood pressure control among South African adults with hypertension. Genes, 13(8), 1394. https://doi.org/10.3390/genes13081394en_US
dc.identifier.issn2073-4425
dc.identifier.urihttps://doi.org/10.3390/genes13081394
dc.identifier.urihttp://hdl.handle.net/10566/7813
dc.language.isoenen_US
dc.publisherMDPIen_US
dc.subjectAmlodipineen_US
dc.subjectNucleotide polymorphismsen_US
dc.subjectBlood pressureen_US
dc.subjectHypertensionen_US
dc.subjectSouth Africaen_US
dc.titleSingle nucleotide polymorphisms in amlodipine-associated genes and their correlation with blood pressure control among South African adults with hypertensionen_US
dc.typeArticleen_US

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