Novel tricycloundecane derivatives as potential N-methyl-Daspartate receptor and calcium channel inhibitors for neuroprotection

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dc.contributor.advisorJoubert, Jacques
dc.contributor.advisorMalan, Sarel
dc.contributor.authorEgunlusi, Ayodeji Olatunde
dc.date.accessioned2014-11-21T10:08:05Z
dc.date.accessioned2024-05-15T07:43:15Z
dc.date.available2014-11-21T10:08:05Z
dc.date.available2024-05-15T07:43:15Z
dc.date.issued2014
dc.description>Magister Scientiae - MScen_US
dc.description.abstractThis study focused on the synthesis of a series of novel tricycloundecane derivatives and evaluation of these compounds for neuroprotection using the fluorescent ratiometric calcium assay that indicates the ability of the test compounds to inhibit NMDA receptors and VGCC. The cycloaddition reaction between p-benzoquinone and monomerised dicyclopentadiene yielded tricycloundeca- 4,9-diene-3,6-dione which was used as the base structure and further derivatised. These derivatives were conjugated with benzylamine to form a series of imines and amines. A total of 10 compounds were synthesised for evaluation of inhibition of calcium influx through NMDA receptor channels and voltage-gated calcium channels. The structures were confirmed using NMR, IR and MS. On the proton NMR, the characteristic AB-quartet system was observed in the region of 1-2 ppm for all the compounds and the aromatic moiety was observed between 6.5-7.5 ppm for the novel polycyclic amines. These, with other functional groups, were used to confirm the individual structuresen_US
dc.identifier.urihttps://hdl.handle.net/10566/15210
dc.language.isoenen_US
dc.publisherUniversity of the Western Capeen_US
dc.rights.holderUniversity of the Western Capeen_US
dc.subjectNeurodegenerative disordersen_US
dc.subjectTricycloundecaneen_US
dc.subjectN-methyl-D-aspartate receptoren_US
dc.subjectVoltage-gated calcium channelen_US
dc.subjectOxidative stressen_US
dc.subjectSynaptoneurosomesen_US
dc.subjectExcitotoxicityen_US
dc.subjectApoptosisen_US
dc.subjectNecrosisen_US
dc.subjectPolycyclic cageen_US
dc.subjectNeuroprotective agentsen_US
dc.subjectFura-2 AMen_US
dc.titleNovel tricycloundecane derivatives as potential N-methyl-Daspartate receptor and calcium channel inhibitors for neuroprotectionen_US
dc.typeThesisen_US

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