Recent Advances in the Development of Antimicrobial and Antifouling Biocompatible Materials for Dental Applications

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dc.contributor.authorRamburrun, P.
dc.contributor.authorPringle, N.A.
dc.contributor.authorDube, A.
dc.contributor.authorAdam, R.Z.
dc.date.accessioned2021-09-07T21:23:52Z
dc.date.available2021-09-07T21:23:52Z
dc.date.issued2021
dc.description.abstractThe risk of secondary bacterial infections resulting from dental procedures has driven the design of antimicrobial and antifouling dental materials to curb pathogenic microbial growth, biofilm formation and subsequent oral and dental diseases. Studies have investigated approaches based primarily on contact-killing or release-killing materials. These materials are designed for addition into dental resins, adhesives and fillings or as immobilized coatings on tooth surfaces, titanium implants and dental prosthetics. This review discusses the recent developments in the different classes of biomaterials for antimicrobial and antifouling dental applications: polymeric drug-releasing materials, polymeric and metallic nanoparticles, polymeric biocides and antimicrobial peptides. With modifications to improve cytotoxicity and mechanical properties, contact-killing and anti-adhesion materials show potential for incorporation into dental materials for long-term clinical use as opposed to short-lived antimicrobial release-based coatings. However, extended durations of biocompatibility testing, and adjustment of essential biomaterial features to enhance material longevity in the oral cavity require further investigations to confirm suitability and safety of these materials in the clinical setting. The continuous exposure of dental restorative and regenerative materials to pathogenic microbes necessitates the implementation of antimicrobial and antifouling materials to either replace antibiotics or improve its rational use, especially in the day and age of the ever-increasing problem of antimicrobial resistance.en_US
dc.identifier.citationRamburrun, Poornima & Pringle, Nadine & Dube, Admire & Adam, Razia & D'Souza, Sarah & Aucamp, Marique. (2021). Recent Advances in the Development of Antimicrobial and Antifouling Biocompatible Materials for Dental Applications. Materials. 14. 3167. 10.3390/ma14123167.en_US
dc.identifier.issn1996-1944
dc.identifier.uri10.3390/ma14123167
dc.identifier.urihttp://hdl.handle.net/10566/6626
dc.language.isoenen_US
dc.publisherMDPIen_US
dc.subjectAntimicrobial and antifouling materialsen_US
dc.subjectDental restorative materialsen_US
dc.subjectBiofilmsen_US
dc.subjectPolymersen_US
dc.subjectRecurrent cariesen_US
dc.titleRecent Advances in the Development of Antimicrobial and Antifouling Biocompatible Materials for Dental Applicationsen_US
dc.typeArticleen_US

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