Recent Advances in the Development of Antimicrobial and Antifouling Biocompatible Materials for Dental Applications
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Date
2021
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Publisher
MDPI
Abstract
The risk of secondary bacterial infections resulting from dental procedures has driven
the design of antimicrobial and antifouling dental materials to curb pathogenic microbial growth,
biofilm formation and subsequent oral and dental diseases. Studies have investigated approaches
based primarily on contact-killing or release-killing materials. These materials are designed for
addition into dental resins, adhesives and fillings or as immobilized coatings on tooth surfaces,
titanium implants and dental prosthetics. This review discusses the recent developments in the
different classes of biomaterials for antimicrobial and antifouling dental applications: polymeric
drug-releasing materials, polymeric and metallic nanoparticles, polymeric biocides and antimicrobial
peptides. With modifications to improve cytotoxicity and mechanical properties, contact-killing and
anti-adhesion materials show potential for incorporation into dental materials for long-term clinical
use as opposed to short-lived antimicrobial release-based coatings. However, extended durations
of biocompatibility testing, and adjustment of essential biomaterial features to enhance material
longevity in the oral cavity require further investigations to confirm suitability and safety of these
materials in the clinical setting. The continuous exposure of dental restorative and regenerative
materials to pathogenic microbes necessitates the implementation of antimicrobial and antifouling
materials to either replace antibiotics or improve its rational use, especially in the day and age of the
ever-increasing problem of antimicrobial resistance.
Description
Keywords
Antimicrobial and antifouling materials, Dental restorative materials, Biofilms, Polymers, Recurrent caries
Citation
Ramburrun, Poornima & Pringle, Nadine & Dube, Admire & Adam, Razia & D'Souza, Sarah & Aucamp, Marique. (2021). Recent Advances in the Development of Antimicrobial and Antifouling Biocompatible Materials for Dental Applications. Materials. 14. 3167. 10.3390/ma14123167.