Comparative analysis of human coronavirus-NL63 ORF3 protein homologues

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dc.contributor.authorFielding, Burtram C.
dc.contributor.authorSuliman, Tasnim
dc.date.accessioned2013-10-12T05:07:05Z
dc.date.available2013-10-12T05:07:05Z
dc.date.issued2009
dc.description.abstractIt has been reported in some studies that the newly discovered human coronavirus NL-63 (HCoVNL63) is one of the most common coronaviruses associated with acute respiratory infections. HCoVNL63 was first isolated in 2004 from a 7 month old infant in Holland. The HCoV-NL63 genome encodes for one accessory protein, ORF3. This reports the computational analysis of human coronavirus NL63 ORF3 by comparing the amino acid sequences of coronavirus ORF3-homologues. The HCoV-NL63 ORF3 gene was found to encode a putative protein ~25.6 kDa in size. ORF3 was predicted to contain three potential transmembrane regions. The amino acid sequence of HCoVNL63 ORF3 was shown to be most similar to HCoV 229E ORF4 (43% identity; 62% similarity).en_US
dc.description.accreditationWeb of Scienceen_US
dc.identifier.citationFielding, B. & Suliman, T. (2009). Comparative analysis of human coronavirus-NL63 ORF3 protein homologues. African Journal of Biotechnology, 8(14): 3175-3178en_US
dc.identifier.issn1684–5315
dc.identifier.urihttp://hdl.handle.net/10566/742
dc.language.isoenen_US
dc.privacy.showsubmitterfalse
dc.publisherAcademic Journalsen_US
dc.rights© 2009 Fielding & Suliman; licensee Academic Journals. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.status.ispeerreviewedtrue
dc.subjectHuman coronavirusen_US
dc.subjectNL-63
dc.subjectAccessory protein ORF3
dc.subjectGene analysis
dc.titleComparative analysis of human coronavirus-NL63 ORF3 protein homologuesen_US
dc.typeArticleen_US

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