Comparative analysis of human coronavirus-NL63 ORF3 protein homologues

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Date

2009

Journal Title

Journal ISSN

Volume Title

Publisher

Academic Journals

Abstract

It has been reported in some studies that the newly discovered human coronavirus NL-63 (HCoVNL63) is one of the most common coronaviruses associated with acute respiratory infections. HCoVNL63 was first isolated in 2004 from a 7 month old infant in Holland. The HCoV-NL63 genome encodes for one accessory protein, ORF3. This reports the computational analysis of human coronavirus NL63 ORF3 by comparing the amino acid sequences of coronavirus ORF3-homologues. The HCoV-NL63 ORF3 gene was found to encode a putative protein ~25.6 kDa in size. ORF3 was predicted to contain three potential transmembrane regions. The amino acid sequence of HCoVNL63 ORF3 was shown to be most similar to HCoV 229E ORF4 (43% identity; 62% similarity).

Description

Keywords

Human coronavirus, NL-63, Accessory protein ORF3, Gene analysis

Citation

Fielding, B. & Suliman, T. (2009). Comparative analysis of human coronavirus-NL63 ORF3 protein homologues. African Journal of Biotechnology, 8(14): 3175-3178