Delphinidin as an antineoplastic agent targeting androgen receptors

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dc.contributor.authorFadaka Adewale
dc.contributor.authorSibuyi Nicole
dc.contributor.authorAlves Leandro
dc.date.accessioned2025-10-02T15:54:04Z
dc.date.available2025-10-02T15:54:04Z
dc.date.issued2025
dc.description.abstractResearchers globally have discovered that both red and green peppers are extremely rich in bioactive phytoconstituents with pharmacological properties. These metabolites are associated with critical physiological functions, including anticancer and health-promoting effects. However, due to insufficient clinical evidence or lack of standardized studies, there are no recommendations regarding their use and dosage. We investigated the potential therapeutic effects of Capsicum chinense flesh as an inhibitor of the androgen receptor through computational studies. To explore potential novel antitumor markers from Capsicum chinense flesh, we employed in silico docking, molecular dynamics simulations, and principal component analysis. Our results consistently demonstrated significant binding across all the receptor models tested, with the potential candidate (Delphinidin) emerged as a promising candidate. This study offers valuable insights into a robust pharmacological approach that could aid in identifying targets with investigative roles in tumor development and provide potential therapeutic options for managing tumors and associated challenges.
dc.identifier.citationL. Miranda-Alves, S. A. Onikanni, A. O. Fadaka, T. N.-P. Dao, N. R. S. Sibuyi, O. E. Amos, M. G. Ajayi, E. Adewole, B. E. Oyinloye, M. H. Le, N. T. A. Nhung, Delphinidin as an Antineoplastic Agent Targeting Androgen Receptors. ChemistrySelect 2025, 10, e01261. https://doi.org/10.1002/slct.202501261
dc.identifier.uridoi.org/10.1002/slct.202501261
dc.identifier.urihttps://hdl.handle.net/10566/21010
dc.language.isoen
dc.publisherWiley
dc.subjectCapsicum
dc.subjectCapsicum chinense
dc.subjectMetabolites
dc.subjectPhy-toconstituents
dc.titleDelphinidin as an antineoplastic agent targeting androgen receptors
dc.typeArticle

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