Microtubular dysfunction and male infertility
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Date
2018
Journal Title
Journal ISSN
Volume Title
Publisher
Korean Society for Sexual Medicine and Andrology
Abstract
Microtubules are the prime component of the cytoskeleton along with microfilaments. Being vital for organelle transport and
cellular divisions during spermatogenesis and sperm motility process, microtubules ascertain functional capacity of sperm.
Also, microtubule based structures such as axoneme and manchette are crucial for sperm head and tail formation. This review
(a) presents a concise, yet detailed structural overview of the microtubules, (b) analyses the role of microtubule structures in
various male reproductive functions, and (c) presents the association of microtubular dysfunctions with male infertility. Considering
the immense importance of microtubule structures in the formation and maintenance of physiological functions of sperm
cells, this review serves as a scientific trigger in stimulating further male infertility research in this direction.
Description
Keywords
Axoneme, Male infertility, Kartagener syndrome, Microtubule-associated proteins
Citation
Gunes, S. et al. (2018). Microtubular dysfunction and male infertility. The World Journal of Men's Health, 2018.