Identification of bacterial pathogenic gene classes subject to diversifying selection

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dc.contributor.advisorHide, Winston
dc.contributor.advisorBajic, Vladimir
dc.contributor.authorPanji, Sumir
dc.contributor.otherFaculty of Science
dc.date.accessioned2013-12-10T14:05:15Z
dc.date.accessioned2024-05-09T08:19:16Z
dc.date.available2011/02/17 13:40
dc.date.available2011/02/17
dc.date.available2013-12-10T14:05:15Z
dc.date.available2024-05-09T08:19:16Z
dc.date.issued2009
dc.descriptionPhilosophiae Doctor - PhD (Biotechnology)en_US
dc.description.abstractAvailability of genome sequences for numerous bacterial species comprising of different bacterial strains allows elucidation of species and strain specific adaptations that facilitate their survival in widely fluctuating micro-environments and enhance their pathogenic potential. Different bacterial species use different strategies in their pathogenesis and the pathogenic potential of a bacterial species is dependent on its genomic complement of virulence factors. A bacterial virulence factor, within the context of this study, is defined as any endogenous protein product encoded by a gene that aids in the adhesion, invasion, colonization, persistence and pathogenesis of a bacterium within a host. Anecdotal evidence suggests that bacterial virulence genes are undergoing diversifying evolution to counteract the rapid adaptability of its host’s immune defences. Genome sequences of pathogenic bacterial species and strains provide unique opportunities to study the action of diversifying selection operating on different classes of bacterial genes.en_US
dc.description.countrySouth Africa
dc.identifier.urihttps://hdl.handle.net/10566/13515
dc.language.isoenen_US
dc.publisherUniversity of the Western Capeen_US
dc.rights.holderUniversity of the Western Capeen_US
dc.subjectHelicobacter pylorien_US
dc.subjectNeisseria meningitidisen_US
dc.subjectVibrio Choleraeen_US
dc.subjectPositive Selectionen_US
dc.subjectVirulence Geneen_US
dc.subjectNucleotide Diversityen_US
dc.subjectStatistical Enrichmenten_US
dc.subjectFunctional Annotationen_US
dc.subjectBiological Processesen_US
dc.subjectMetabolic Pathwaysen_US
dc.titleIdentification of bacterial pathogenic gene classes subject to diversifying selectionen_US
dc.typeThesisen_US

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