Functional landscape of SARS-CoV-2 cellular restriction

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dc.contributor.authorMartin-Sancho, Laura
dc.contributor.authorLewinski, Mary K.
dc.contributor.authorShaw, Megan L.
dc.date.accessioned2022-07-19T13:12:09Z
dc.date.available2022-07-19T13:12:09Z
dc.date.issued2021
dc.description.abstractA deficient interferon (IFN) response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has been implicated as a determinant of severe coronavirus disease 2019 (COVID-19). To identify the molecular effectors that govern IFN control of SARS-CoV-2 infection, we conducted a large-scale gain-of-function analysis that evaluated the impact of human IFN-stimulated genes (ISGs) on viral replication. A limited subset of ISGs were found to control viral infection, including endosomal factors inhibiting viral entry, RNA binding proteins suppressing viral RNA synthesis, and a highly enriched cluster of endoplasmic reticulum (ER)/Golgi-resident ISGs inhibiting viral assembly/egress.en_US
dc.identifier.citationMartin-Sancho, L. et al. (2021). Functional landscape of SARS-CoV-2 cellular restriction. Molecular Cell, 81(12), 2656 - 2668. 10.1016/j.molcel.2021.04.008en_US
dc.identifier.issn1097-4164
dc.identifier.uri10.1016/j.molcel.2021.04.008
dc.identifier.urihttp://hdl.handle.net/10566/7616
dc.language.isoenen_US
dc.publisherCell Pressen_US
dc.subjectCovid-19en_US
dc.subjectInnate immunityen_US
dc.subjectProtein bindingen_US
dc.subjectTumoren_US
dc.subjectBioscienceen_US
dc.titleFunctional landscape of SARS-CoV-2 cellular restrictionen_US
dc.typeArticleen_US

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