Functional landscape of SARS-CoV-2 cellular restriction
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Date
2021
Journal Title
Journal ISSN
Volume Title
Publisher
Cell Press
Abstract
A deficient interferon (IFN) response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has been implicated as a determinant of severe coronavirus disease 2019 (COVID-19). To identify the molecular effectors that govern IFN control of SARS-CoV-2 infection, we conducted a large-scale gain-of-function analysis that evaluated the impact of human IFN-stimulated genes (ISGs) on viral replication. A limited subset of ISGs were found to control viral infection, including endosomal factors inhibiting viral entry, RNA binding proteins suppressing viral RNA synthesis, and a highly enriched cluster of endoplasmic reticulum (ER)/Golgi-resident ISGs inhibiting viral assembly/egress.
Description
Keywords
Covid-19, Innate immunity, Protein binding, Tumor, Bioscience
Citation
Martin-Sancho, L. et al. (2021). Functional landscape of SARS-CoV-2 cellular restriction. Molecular Cell, 81(12), 2656 - 2668. 10.1016/j.molcel.2021.04.008